Spargias Konstantinos Cardiologist

Doctoral thesis

• Prognostic variables in survivors of acute myocardial infarction with clinical evidence of heart failure. (1999) University of Leeds, UK

Fellowship in Societies, Membership in Journal Editorial Committees

• Hellenic Cardiac Society

• European Society of Cardiology

Editorial Boards:

• Hellenic Journal of Cardiology. Guest Editor

• Continuing Cardiology Education. Guest Editor

AD-HOC REVIEWER for peer-reviewed international journals:
• AJC, JACC, Circulation, JOIC, JIC, IJC, Cardiology

Work Experience

• 2001-2010: Interventional Cardiologist, Dept of Cardiology A, Onassis Cardiac Surgery Centre. Chief of Percutaneous Valve Program since December 2009.

• 1999-2001: Interventional Cardiology Clinical Fellowship, Division of Cardiology, Vancouver General Hospital & Health Sciences Center and St Paul’s Hospital, in affiliation with the University of British Columbia, Vancouver, BC, Canada 

• 1995-1999: Senior Registrar (AH) in Cardiology, Yorkshire Heart Centre, Leeds, West Yorkshire, UK

Education Experience:

• Medical student and Cardiology fellows training at OCSC (2001-2010)

Clinical & Research Interest

Clinical Interest:

• Coronary Artery Disease, interventional therapy

• Structural Heart Disease, interventional therapy

• Transcatheter Heart Valve therapies

•  

Research Interest:

• Transcatheter Heart Valve therapies

Books

• KS Spargias, AS Hall. Angiotensin-converting enzyme inhibition therapy after acute myocar-dial infarction. 100 years of the Renin-Angiotensin System. Ed. Hughes associates, 1998, Oxford, UK 

• KS Spargias, IM Penn. Cases contribution in: Cases Studies in Interventional Cardiology. MT Rothman. Ed. M Dunitz Ltd, 2003, London, UK

• K Spargias. Author in: Percutaneous Treatment of Left Side Cardiac Valves. C Tamburino and GP Ussia, Ed. Springer-Verlag, 2010, Milan, Italy

• Spargias K . “Balloon Aortic Valvuloplasty” in Textbook: Cardiac Valvular Medicine. Rajaman-nan NM (Ed.). 2013, pp 83-91. Springer, NY, USA

• M Chrissoheris, K Spargias. Edge-to-edge repair of severe mitral regurgitation (MR) using multiple clips in a patient with a very broad MR jet. 2013, p104 in Mitraclip Case Collection. Abbott Vascular, Belgium

Recent Publications

• Haberman D, Taramasso M, Czarnecki A, Kerner A, Chrissoheris M, Spargias K, Poles L, Agmon Y, Scianna S, Beeri R, Lotan C, Maisano F, Shuvy M. Salvage MitraClip in severe secondary mitral regurgitation complicating acute myocardial infarction: data from a multicentre international study. Eur J Heart Fail. 2019 Sep;21(9):1161-1164. doi: 10.1002/ejhf.1565. Epub 2019 Aug 5.

• Simonato M, Webb J, Bleiziffer S, Abdel-Wahab M, Wood D, Seiffert M, Schäfer U, Wöhrle J, Jochheim D, Woitek F, Latib A, Barbanti M, Spargias K, Kodali S, Jones T, Tchetche D, Coutinho R, Napodano M, Garcia S, Veulemans V, Siqueira D, Windecker S, Cerillo A, Kempfert J, Agrifoglio M, Bonaros N, Schoels W, Baumbach H, Schofer J, Gaia DF, Dvir D. Current Generation Balloon-Expandable Transcatheter Valve Positioning Strategies During Aortic Valve-in-Valve Procedures and Clinical Outcomes. JACC Cardiovasc Interv. 2019 Aug 26;12(16):1606-1617. doi: 10.1016/j.jcin.2019.05.057.

• Asmarats L, Perlman G, Praz F, Hensey M, Chrissoheris MP, Philippon F, Ofek H, Ye J, Puri R, Pibarot P, Attinger A, Moss R, Bédard E, Moschovitis A, Reineke D, Lauck S, Blanke P, Leipsic J, Spargias K, Windecker S, Webb JG, Rodés-Cabau J. Long-Term Outcomes of the FORMA Transcatheter Tricuspid Valve Repair System for the Treatment of Severe Tricuspid Regurgitation: Insights From the First-in-Human Experience. JACC Cardiovasc Interv. 2019 Aug 12;12(15):1438-1447. doi: 10.1016/j.jcin.2019.04.038.

• Lim DS, Kar S, Spargias K, Kipperman RM, O’Neill WW, Ng MKC, Fam NP, Walters DL, Webb JG, Smith RL, Rinaldi MJ, Latib A, Cohen GN, Schäfer U, Marcoff L, Vandrangi P, Verta P, Feldman TE. Transcatheter Valve Repair for Patients With Mitral Regurgitation: 30-Day Results of the CLASP Study. JACC Cardiovasc Interv. 2019 Jul 22;12(14):1369-1378. doi: 10.1016/j.jcin.2019.04.034. Epub 2019 Jun 26.

• Duncan A, Moat N, Simonato M, de Weger A, Kempfert J, Eggebrecht H, Walton A, Hellig F, Kornowski R, Spargias K, Mendiz O, Makkar R, Guerrero M, Rihal C, George I, Don C, Iadanza A, Bapat V, Welsh R, Wijeysundera HC,  Wood D, Sathananthan J, Danenberg H, Maisano F, Garcia S, Gafoor S, Nombela-Franco L, Cobiella J, Dvir D. Outcomes Following Transcatheter Aortic Valve Replacement for Degenerative Stentless Versus Stented Bioprostheses. JACC Cardiovasc Interv. 2019 Jul 8;12(13):1256-1263. doi: 10.1016/j.jcin.2019.02.036. Epub 2019 Jun 12.

• Chrissoheris MP, Halapas A, Papadopoulos K, Kourkoveli P, Nikolaou I, Bouboulis N, Pattakos G, Spargias K. Transcatheter mitral valve-in-ring implantation by the transfemoral approach: First experience in Greece. Hellenic J Cardiol. 2019 Jun 5. pii: S1109-9666(19)30053-3. doi: 10.1016/j.hjc.2019.05.003. [Epub ahead of print]

• Papadopoulos K, Chrissoheris M, Nikolaou I, Spargias K. Edge-to-edge mitral valve repair for acute mitral valve regurgitation due to papillary muscle rupture: a case report. Eur Heart J Case Rep. 2019 Feb 6;3(1):ytz001. doi: 10.1093/ehjcr/ytz001. eCollection 2019 Mar.

• Pattakos G, Chrissoheris M, Halapas A, Papadopoulos K, Kourkoveli P, Bouboulis N, Pattakos S, Spargias K. Transcatheter Aortic Valve Replacement in a Patient With Dextrocardia and Situs Inversus Totalis. Ann Thorac Surg. 2019 Jan;107(1):e33-e35. doi: 10.1016/j.athoracsur.2018.05.041. Epub 2018 Aug 16.

• McElhinney DB, Aboulhosn JA, Dvir D, Whisenant B, Zhang Y, Eicken A, Ribichini F, Tzifa A, Hainstock MR, Martin MH, Kornowski R, Schubert S, Latib A, Thomson JDR, Torres AJ, Meadows J, Delaney JW, Guerrero ME, Salizzoni S, El-Said H, Finkelstein A, George I, Gewillig M, Alvarez-Fuente M, Lamers L, Cheema AN, Kreutzer JN, Rudolph T, Hildick-Smith D, Cabalka AK; VIVID Registry. Mid-Term Valve-Related Outcomes After Transcatheter Tricuspid Valve-in-Valve or Valve-in-Ring Replacement. J Am Coll Cardiol. 2019 Jan 22;73(2):148-157. doi: 10.1016/j.jacc.2018.10.051.

• Chrissoheris MP, Halapas A, Papadopoulos K, Spargias K. Transcatheter MitraClip implantation facilitated by transthoracic echocardiography. J Echocardiogr. 2018 Jun;16(2):91-92. doi: 10.1007/s12574-017-0358-0. Epub 2017 Nov 27.

• Pibarot P, Simonato M, Barbanti M, Linke A, Kornowski R, Rudolph T, Spence M, Moat N, Aldea G, Mennuni M, Iadanza A, Amrane H, Gaia D, Kim WK, Napodano M, Baumbach H, Finkelstein A, Kobayashi J, Brecker S, Don C, Cerillo A, Unbehaun A, Attias D, Nejjari M, Jones N, Fiorina C, Tchetche D, Philippart R, Spargias K, Hernandez JM, Latib A, Dvir D. Impact of Pre-Existing Prosthesis-Patient Mismatch on Survival Following Aortic Valve-in-Valve Procedures. JACC Cardiovasc Interv. 2018 Jan 22;11(2):133-141. doi: 10.1016/j.jcin.2017.08.039.

• Bapat V, Rajagopal V, Meduri C, Farivar RS, Walton A, Duffy SJ, Gooley R, Almeida A, Reardon MJ, Kleiman NS, Spargias K, Pattakos S, Ng MK, Wilson M, Adams DH, Leon M, Mack MJ, Chenoweth S, Sorajja P; Intrepid Global Pilot Study Investigators. Early Experience With New Transcatheter Mitral Valve Replacement. J Am Coll Cardiol. 2018 Jan 2;71(1):12-21. doi: 10.1016/j.jacc.2017.10.061. Epub 2017 Nov 16.

• Taggart NW, Cabalka AK, Eicken A, Aboulhosn JA, Thomson JDR, Whisenant B, Bocks ML, Schubert S, Jones TK, Asnes JD, Fagan TE, Meadows J, Hoyer M, Martin MH, Ing FF, Turner DR, Latib A, Tzifa A, Windecker S, Goldstein BH, Delaney JW, Kuo JA, Foerster S, Gillespie M, Butera G, Shahanavaz S, Horlick E, Boudjemline Y, Dvir D, McElhinney DB; VIVID Registry. Outcomes of Transcatheter Tricuspid Valve-in-Valve Implantation in Patients With Ebstein Anomaly. Am J Cardiol. 2018 Jan 15;121(2):262-268. doi: 10.1016/j.amjcard.2017.10.017. Epub 2017 Oct 19.

• Praz F, Spargias K, Chrissoheris M, et al. Compassionate use of the PASCAL transcatheter mitral valve repair system for patients with severe mitral regurgitation: a multicentre, prospective, observational, first-in-man study. Lancet. 2017;390:773-780

• Kourkoveli P, Spargias K, Hahalis G. TAVR in 2017-What we know? What to expect? J Geriatr Cardiol. 2018 Jan;15(1):55-60. doi: 10.11909/j.issn.1671-5411.2018.01.005.

• FORWARD Study Investigators (Spargias K) Clinical Outcomes With a Repositionable Self-Expanding Transcatheter Aortic Valve Prosthesis: The International FORWARD Study. J Am Coll Cardiol. 2017;70(7):845-853.

• K Spargias, A Manginas, G Pavlides, M Khoury, G Stavridis, P Rellia, A Smirli, A Thanopoulos, M Balanika, S Polymeros, S Thomopoulou, G Athanassopoulos, G Karatasakis, R Mastorakou, S Lacoumenta, A Michalis, P Alivizatos, D Cokkinos. Transcatheter Aortic Valve Implantation: First Greek Experience. Hellenic J Cardiol 2008;49:397-407.

• Spargias K, Chrissoheris M, Halapas A, Nikolaou J, Tsolakis A, Bouboulis N, Pattakos S. Percutaneous Mitral Valve Repair Using the Edge-to-Edge Technique: First Greek Experience. Hellenic J Cardiol 2012;53:343-51.

• K Spargias, K Toutouzas, M Chrissoheris, Synetos A, Halapas A, Paizis I, Latsios G, Stahogianis K, Papametzelopoulos S, Zanos S, Pavlides G, Zacharoulis A, Antoniades A, Stefanadis C. The ATHENS TAVI Registry of newer generation transfemoral aortic valves. 30 day outcomes. Hellenic J Cardiol 2013;54:18-24.

• Chrissoheris M, Ziakas A, Halapas A, Hadjimiltiades S, Styliadis I, Karvounis C, Nikolaou I, Spargias K. Acute Invasive Hemodynamic Effects of Transcatheter Aortic Valve Implantation. J Heart Valve Disease 2016, Mar;25(2):162-172.

• K Spargias, A Halapas, M Chrissoheris, N Bouboulis, S Skardoutsos, J Nikolaou, A Tsolakis, C Mourmouris, S Pattakos. Transaortic Aortic Valve Replacement Using The Edwards Sapien-XT Valve And The Medtronic Corevalve. Initial Experience. Hellenic J Cardiol 2014;55:288-93.

• M Chrissoheris, A Tsangaris, A Halapas, K Spargias. Transcatheter Aortic Valve Replacement in Patients with Prior Chest Irradiation and Severe Aortic Stenosis. J Radiol Oncology 2016, In press.

• Spargias K, Dvir D. TAVR In Failed Bioprostheses. The Valve-In-Valve Approach. Cardiac Interv Today 2013; 45-8.

• Chrissoheris M, Halapas A, Nikolaou I, Boumboulis N, Pattakos S, Spargias K. The Abbott Vascular MitraClip: Patient Selection and How to Obtain the Best Outcomes. Hellenic J Cardiol. 2015;56 Suppl A:31-8.

• Tzikas A, Chrissoheris M, Halapas A, Spargias K. PorticoTM Transcatheter Heart Valve. Hellenic J Cardiol. 2015;56 Suppl A:15-9.

• Halapas A, Chrissoheris M, Bouboulis N, Skardoutsos S, Nikolaou I, Pattakos S, Spargias K. The SAPIEN-XT and SAPIEN-3 Valves: How to Implant and Obtain the Best Outcomes. Hellenic J Cardiol. 2015;56 Suppl A:9-14.

• Spargias K. The era of transcatheter valve therapy. Where are we? Hellenic J Cardiol. 2015;56 Suppl A:1-3.

• Wendler O, Walther T, Schroefel H, Lange R, Treede H, Fusari M, Rubino P, Thomas M; SOURCE investigators (K Spargias). Transapical aortic valve implantation: mid-term outcome from the SOURCE registry. Eur J Cardiothorac Surg 2013;43:505-11.

• Spargias K, Tzifa A, Chrissoheris M, Boumpoulis N, Nikolaou I, Pattakos E. Transapical closure of mitral prosthetic paravalvular leak. Hellenic J Cardiol 2013;54:397-400.

• A Halapas, M Chrissoheris, I Nikolaou, N Bouboulis, K Spargias. Challenging Transfemoral Valve-in-Valve Implantation in a Degenerated Stentless Bioprosthetic Aortic Valve. J Invasive Cardiol 2015;56:347-50

• Papavasileiou LP, Halapas A, Chrisocheris M, Bellos K, Bouboulis N, Pattakos S, Spargias K, Apostolopoulos T. Sudden Death After ranscatheter Aortic Valve Implantation. Are Bradyarrhythmias Always The Cause? JAFIB. 2015;8:39-41.

• K Spargias, G Dangas. Percutaneous Treatment of Left Side Cardiac Valves. C Tamburino and GP Ussia, Ed. Springer-Verlag, 2010, Milan, Italy.

• Chrissoheris M, Spargias K. “Balloon Aortic Valvuloplasty” in Textbook: Cardiac Valvular Medicine. Rajamannan NM (Ed.). Springer-Verlag, 2013, London, UK.

• Spargias K.
Percutaneous aortic valve implantation: present and future. Controlled clinical application before the results of randomized trials. Hellenic J Cardiol 2009;50:237-44.

• K Spargias, M Gyöngyösi, R Hemetsberger, A Posa, N Pavo, IJ Pavo, K Huber, Z Petrasi, O Petnehazy, R Pogge von Strandmann, SR Stock, D Glogar, G Maurer, NM Rajamannan. Valvuloplasty with a Paclitaxel-Eluting Balloon Prevents Restenosis in an Experimental Model of Aortic Stenosis. J Heart Valve Disease 2014 Jul;23(4):484-91.

• Spargias K, Polymeros S, Dimopoulos A, Manginas A, Pavlides G, Balanika M, Smirli A, Stavridis G, Dangas G, Cokkinos DV. The predictive value and evolution of N-Terminal Pro-B-Type Natriuretic Peptide levels following Transcutaneous Aortic Valve Implantation. J Interv Cardiol 2011;24:462-9.

• Balanika M, Smyrli A, Samanidis G, Spargias K, Stavridis G, Karavolias G, Khoury M, Voudris V, Lacoumenta S. Anesthetic Management of Patients Undergoing Transcatheter Aortic Valve Implantation. J Cardiothorac Vasc Anesth 2013 Dec 5. [Epub ahead of print]

• Spargias K, Alexopoulos E, Thomopoulou S, Dimopoulos A, Manginas A, Pavlides G, Voudris V, Karatassakis G, Athanassopoulos G, Cokkinos DV. Effect of balloon valvuloplasty in patients with severe aortic stenosis on levels of N-terminal pro-B-type natriuretic peptide. Am J Cardiol 2009;104:846-849.

• Dvir D, Assali A, Spargias K, Kornowski R. Percutaneous aortic valve implantation in patients with coronary artery disease: review of therapeutic strategies. J Invasive Cardiol 2009;21:E237-41.

• Chrissoheris M, Ferti A, Spargias K. Early prosthetic valve endocarditis complicating repeated attempts at CoreValve implantation. J Invasive Cardiol 2011;23:E291-2.

• Spargias K, Milewski K, Debinski M, Buszman PP, Cokkinos DV, Pogge R, Buszman P. Drug delivery at the aortic valve tissues of healthy domestic pigs with a paclitaxel eluting valvuloplasty balloon. J Interv Cardiol 2009;22:291-8.

• Wilczek K, Chodór P, Przybylski R, Krasoń M, Niklewski T, Nadziakiewicz P, Głowacki J, Kusa J, Goddyn D, Spargias K, Zembala M. First in Poland transcatheter, transfemoral aortic valve implantation in elderly symptomatic high-risk patient with aortic stenosis-novel Zabrze experience. Kardiol Pol 2009;67:219-23.

• Kolettis TN, Spargias K, Stavridis GT. Combined transapical aortic valve implantation with coronary artery bypass grafting in a young patient with porcelain aorta. Hellenic J Cardiol 2009;50:79-82.

• Trendafilova D , Jorgova J, Simeonov P. Acknowledgement to Dr K Spargias. First Transfemoral Aortic Valve Implantation In Bulgaria. The Internet Journal of Cardiology 2010;9:2.