Papaspyrou Konstantinos Ent specialist

Courses-Workshops-Hands on Experience

• Stimmrehabilitation nach Laryngektomie mittels stimmprothetischer Versorgung („Voice rehabilitation after laryngectomy with voice prostheses“), University of Mainz, E.N.T. Clinic, Mainz, Germany, 16.10.2004.

• Mainzer Ultraschallkurse fűr HNO-Ärzte und Kieferchirurgen 2005, (Ultrasonography Seminars for Otorhinolaryngologists and Oral Surgeons), University of Mainz, E.N.T. Clinic, Mainz, Germany (Continuing Medical Education, Credits 63)

• International Workshop on Micro-Endoscopic Sinus Surgery, University of Mainz, E.N.T. Clinic, Mainz, Germany, 02-04.06.2005 (Continuing Medical Education, Credits 23)

• International Workshop on Micro-Endoscopic Sinus Surgery, University of Mainz, E.N.T. Clinic, Mainz, Germany, 02- 04.03.2006 (Continuing Medical Education, Credits 23)

• 6^th Wullstein Symposium, (Symposium on Ear Surgery and Cochlear Implantation), Würzburg, Germany, 7-12.12.2006

• Mainzer Ultraschallkurse fűr HNO-Ärzte und Kieferchirurgen 2007, (Ultrasonography Seminars for Otorhinolaryngologists and Oral Surgeons), University of Mainz, E.N.T. Clinic, Mainz, Germany (Continuing Medical Education, Credits 63)

• International Workshop on Micro-Endoscopic Sinus Surgery, University of Mainz, E.N.T. Clinic, Mainz, Germany, 01-03.03.2007 (Continuing Medical Education, Credits 23)

• 11th Head and Neck Cadaver Dissection Workshop, E.N.T. Clinic, Evangelismos Hospital, Athens, Greece  (Temporal Bone Dissection, Surgery of the nasal septum, Functional Endoscopic Sinus Surgery (F.E.S.S.), Surgery of the Salivary Glands, Larynx Surgery, Rhinoplasty, Otoplasty),  10-16.03.2007

• Mainzer Ultraschallkurse fűr HNO-Ärzte und Kieferchirurgen 2008, (Ultrasonography Seminars for Otorhinolaryngologists and Oral Surgeons), University of Mainz, E.N.T. Clinic, Mainz, Germany (Continuing Medical Education, Credits 63)

• International Workshop on Micro-Endoscopic Sinus Surgery, University of Mainz, E.N.T. Clinic, Mainz, Germany, 21-23.02.2008 (Continuing Medical Education, Credits 23)

• 12th Head and Neck Cadaver Dissection Workshop, E.N.T. Clinic, Evangelismos Hospital, Athens, Greece  (Temporal Bone Dissection, Surgery of the nasal septum, Functional Endoscopic Sinus Surgery (F.E.S.S.), Surgery of the Salivary Glands, Larynx Surgery, Rhinoplasty, Otoplasty), 15-21.03.2008

• 9th International Training Course on Endoscopic and Microscopic Sinus Surgery, Marburg, Germany, 31.08-02.09.2008

• Rhino Days 2009, International Symposium on Nasal Obstruction and Balloon Sinuplasty, Marburg, Germany, 15-17.01.2009

• 14th Head and Neck Cadaver Dissection Workshop, E.N.T. Clinic, Evangelismos Hospital, Athens, Greece  (Temporal Bone Dissection, Surgery of the nasal septum, Functional Endoscopic Sinus Surgery (F.E.S.S.), Surgery of the Salivary Glands, Larynx Surgery, Rhinoplasty, Otoplasty), 07-12.03.2009

• 10th International Training Course on Endoscopic and Microscopic Sinus Surgery, Marburg, Germany, 30.08-01.09.2009

• Mainzer Ultraschallkurse fűr HNO-Ärzte und Kieferchirurgen 2010, (Ultrasonography Seminars for Otorhinolaryngologists and Oral Surgeons), University of Mainz, E.N.T. Clinic, Mainz, Germany (Continuing Medical Education, Credits 63)

• 15th Head and Neck Cadaver Dissection Workshop, E.N.T. Clinic, Evangelismos Hospital, Athens, Greece  (Temporal Bone Dissection, Surgery of the nasal septum, Functional Endoscopic Sinus Surgery (F.E.S.S.), Surgery of the Salivary Glands, Larynx Surgery, Rhinoplasty, Otoplasty), 19-21.03.2010

• Mainzer Ultraschallkurse fűr HNO-Ärzte und Kieferchirurgen 2011, (Ultrasonography Seminars for Otorhinolaryngologists and Oral Surgeons), University of Mainz, E.N.T. Clinic, Mainz, Germany (Continuing Medical Education, Credits 63)

• Kurs: Tracheoskopie und Bronchoskopie bei Kindern (Course: Tracheoscopy and Bronchoscopy in children), 11^th Annual Meeting of the German Academy of Oto-Rhino-Laryngology, Head and Neck Surgery, 19.-20.05.2012, Mainz, Germany, 19.05.2012

• Kurs: Stridor und Atemwegsdiagnostik bei Säuglingen und Kindern (Course: Stridor and Airway Diagnostics in infants and children), 11^th Annual Meeting of the German Academy of Oto-Rhino-Laryngology, Head and Neck Surgery, 19.- 20.05.2012, Mainz, Germany, 20.05.2012

PhD/ Thesis

Immunohistochemical analysis of Fascin expression in squamous cell carcinomas of the Head and Neck (Immunohistochemische Analyse der Fascinexpression in Platenepithelkarzinomen des Kopf-Hals-Bereiches), from the Department of Otorhinolaryngology, Head- and Neck Surgery (E.N.T.) of the University of Mainz Medical School´s Hospital, Germany (Director: Univ.-Prof. Dr. med. Dr. h. c. mult. Wolf J. Mann) (07/2009)

Editorial Boards

AD-HOC REVIEWER for peer-reviewed international journals

• Skull Base Reports

• Head Neck

• European Archives of Oto-Rhino-Laryngology and Head & Neck

• Hormones Journal

• World Journal of Surgical Oncology

• Webmed Central

• Endocrine-Related Cancer

• Clinical Chemistry and Laboratory Medicine (CCLM)

Professional Experience

• 05.07.2004-31.07.2012: Salaried employment as a Resident and consequently as an Otorhinolaryngology Specialist (Facharzt) at the Department of Otorhinolaryngology, Head- and Neck Surgery (E.N.T.) of the University of Mainz Medical School´s Hospital, Germany (Director: Univ.-Prof. Dr. med. Dr. h. c. mult. Wolf J. Mann)

• March 2013- today: Private Practice

• March 2013- today: Otorhinolaryngologist, Hygeia Hospital

• August 2013- today: Otorhinolaryngologist, Mitera Hospital

Education Experience

• Education of students of the University of Mainz Medical School in Otorhinolaryngology as well as participation as an examiner in the final oral examinations in this lesson

• Participation at the internal Grand Rounds of the Department of Otorhinolaryngology, Head- and Neck Surgery (E.N.T.) of the University of Mainz Medical School´s Hospital with presentations

• Participation as a Trainer at the Mainzer Ultraschallkurse für HNO-Ärzte und Kieferchirurgen 2012/13 Grundkurs der Kopf- Halssonographie (Ultrasonography Seminars for Otorhinolaryngologists and Oral Surgeons-Basic Level Course), 29-30.06.2012, University of Mainz, E.N.T. Clinic, Mainz, Germany.

Clinical and Research Interest

Clinical Interest

• Neurootology 
  (Diagnosis & Therapy of Hearing loss, Vertigo/Dizziness, Tinnitus, including intratympanic dexamethasone therapy under local anesthesia)

• Pediatric Otorhinolaryngology

Surgical Spectrum Highlights

• Microsurgery of the Larynx with the CO2 Laser for benign & malignant lesions (Phonosurgery, Surgery of cancer of larynx & hypopharynx)

• Posterior cordotomy with the CO2 Laser for vocal cord paralysis

• Vocal Cord Augmentation–Injection Laryngoplasty

• Functional Endoscopic Sinus Surgery (FESS)

• Surgical Treatment of Snoring – Sleep Apnea [including LAUP (Laser-assisted uvulopalatoplasty) & UPPP (Uvulopalatopharyngoplasty)]

• Endoscopic surgical correction of nasal septum deviation

• Endoscopic submucosal photocoagulation of the hypertrophic inferior nasal turbinates with the Diode Laser under local anesthesia

• Tonsillectomy – Endoscopic Adenoidectomy in adults and children

• Myringotomy- Grommet (ventilation-myringostomy tube) insertion under local anesthesia

Most of the above-mentioned procedures take place as

• • One Day Surgery and with

  • Minimal Invasive Surgery

Research Interest: 

• Head and Neck Paragangliomas (glomus tumors) (9 relevant publications in international peer-reviewed journals)

• Scientific presentations in international medical congresses (18)

• Scientific presentations in Greek medical congresses (12)

Recent Publications

1.   Fliedner SM, Shankavaram U, Marzouca G, Elkahloun A, Jochmanova I, Daerr R, Linehan WM, Timmers H, Tischler AS, Papaspyrou K, Brieger J, de Krijger R, Breza J, Eisenhofer G, Zhuang Z, Lehnert H, Pacak K.
Hypoxia-Inducible Factor 2α Mutation-Related Paragangliomas Classify as Discrete Pseudohypoxic Subcluster.
Neoplasia. 2016 Sep;18(9):567-76.

2.  Papaspyrou K, Brochhausen C, Schmidtmann I, Fruth K, Gouveris H, Kirckpatrick J, Mann   W, Brieger J.
Fascin upregulation in primary head and neck squamous cell carcinoma is associated to lymphatic metastasis.
Oncol Lett. 2014 Jun;7(6):2041-2046.

3.   Bickmann JK, Sollfrank S, Schad A, Musholt TJ, Springer E, Miederer M, Bartsch O, Papaspyrou K, Koutsimpelas D, Mann WJ, Weber MM, Lackner KJ, Rossmann H, Fottner C.
Phenotypic variability and risk of malignancy in SDHC-linked paragangliomas: lessons from three unrelated cases with an identical germline mutation (p.Arg133*).
J Clin Endocrinol Metab. 2014 Mar;99(3):E489-96.

4. Papathomas TG, Gaal J, Corssmit EP, Oudijk L, Korpershoek E, Heimdal K, Bayley JP, Morreau H, van Dooren M, Papaspyrou K, Schreiner T, Hansen T, Andresen PA, Restuccia DF, van Kessel I, van Leenders GJ, Kros JM, Looijenga LH, Hofland LJ, Mann W, van Nederveen FH, Mete O, Asa SL, de Krijger RR, Dinjens WN.
Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis.
Eur J Endocrinol. 2013 Nov 22;170(1):1-12.

5.  Miederer M, Fottner C, Rossmann H, Helisch A, Papaspyrou K, Bartsch O, Mann WJ, Musholt TJ, Weber MM, Lackner KJ, Schreckenberger M.
High incidence of extraadrenal paraganglioma in families with SDHx syndromes detected by functional imaging with [18F]fluorodihydroxyphenylalanine PET.
Eur J Nucl Med Mol Imaging. 2013 Jun;40(6):889-96.

6.   Papaspyrou K, Welkoborsky HJ, Gouveris H, Mann WJ.  
Malignant and benign sinonasal paragangliomas.
Laryngoscope. 2013 Aug;123(8):1830-6.

7.   Papaspyrou K, von Creytz H, Kolonko K, Mewes T, Mann W, Scharrer I.
[Bleeding and coagulation disorders in tonsillectomies].
HNO. 2012 Jun;60(6):511-7. [Article in German]

8. Papaspyrou K, Mewes T, Rossmann H, Fottner C, Schneider-Raetzke B, Bartsch O, Schreckenberger M, Lackner KJ, Amedee RG, Mann WJ.
Head and neck paragangliomas: Report of 175 patients (1989-2010).
Head Neck. 2012 May;34(5):632-7.

9. Papaspyrou K, Mewes T, Tóth M, Schmidtmann I, Amedee RG, Mann   WJ.
Hearing results after hypotympanotomy for glomus tympanicum tumors.
Otol Neurotol. 2011 Feb;32(2):291-6.

10.   Papaspyrou K, Mann WJ, Amedee RG.
Management of head and neck paragangliomas: review of 120 patients.
Head Neck. 2009 Mar;31(3):381-7.