Zervomanolakis Ioannis Obstetrician - Gynecologist

Board Member

• Secretary of the Greek Society for Fertility Preservation

• Greek Society for Obstetrics and Gynecology

• Greek Society for Gynecological Endocrinology

• German and Austrian Society for Obstetrics and Gynecology

• German and Austrian Society for Reproductive Endocrinology and Assisted Reproduction

• European Society of Human Reproduction and Embryology (ESHRE)

• American Society for Reproductive Medicine (ASRM)

• Rotary Club Athens-Kifisia

Professional Experience

• 06/2015-11/2020: Partner, CEO ans Vice President. IVF Unit Institute of Life, IASO Clinic, Athens.

• 07/2009-present: Owner of the practice Woman Center Athens- Care & Cure

• 07/2009-05/2015: Consultant. IVF Unit. Maternity Clinic Mitera, Athens.

• 6/2006-5/2009: Fellowship in Reproductive Endocrinology. Consultant (Stellvertretender Direktor), Clinical Division of Gynecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria

• 8/06/2006: Board certification OBGYN, Nordrhein Doctor´s Chamber, Düsseldorf, Germany

RESIDENCY OBGYN

• 8/2001-5/2006: Residency in Germany, PhD University of Bonn

• 1/2001-7/2001: Urological Clinic of Johanniter Medical Center, Oberhausen, Germany.

• 9/1998-1/2001 : General medicine Internship and Clinic of General Surgery in the Ierapetra Medical Center, Ierapetra, Greece.

Clinical and Research Interest

Clinical Interest:

Fertility preservation; Performance of the first ovarian tissue retransplantations in Austria; Infertility; In Vitro Fertilization; In Vitro Maturation of oocytes and ovarian tissue; Reproductive surgery; advanced endoscopic surgery; reproductive options for women with cancer; premature ovarian failure; endometriosis; menstrual disorders; dysfunctional uterine bleeding; polycystic ovarian syndrome; hirsutism; recurrent pregnancy loss (1st trimester); menopause

Research Interest: 

Embryo and cell line culture, IVF and ICSI, cryopreservation of ovarian tissues and in vitro maturation of ovarian follicles from women before chemotherapy, in vitro stimulation of ovarian tissues, intracellular signal transduction pathways mediated by G-protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTK) in pituitary and extrapituitary cells

Research Experience

• 12/2004-1/2005 : Visiting fellow in the Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Washington D.C. Subject: ‘intracellular signal transduction pathways mediated by GnRH receptors and receptor tyrosine kinases in GT1-7 immortalized hypothalamic neuronal cell lines’.

• 10/2001-5/2004: Doctorate student in the Department of Gynecological Endocrinology and Reproduction Medicine, University of Bonn, Germany. Subject: ‘Correlation of the embryo quality until the embryo transfer with the use of GnRH agonists versus GnRH antagonists in assisted reproduction’.

• 6/2002 and 11/2003: Rotation in the Department of Gynecological Endocrinology and Infertility, Yale University´s School of Medicine, Connecticut, USA and  Sydney University, Sydney, Australia

Awards

• Research Prize of the Greek Society for Gynecological Endocrinology, 30.01.11. Subject of the study: “Viability of ovarian tissue before and after cryopreservation and thawing: A pilot study”.

• Research Prize of the Austrian Society for Obstetrics and Gynecology, 24.05.08. Subject of the study: “Development of a perifusion system for In vitro Maturation and In vitro Stimulation of murine ovarian tissue”.

• Research Prize of the Austrian Society for Reproductive Medicine and Endocrinology, 22.09.07. Subject of the study: “Anti-Müllerian Hormone (AMH) and Inhibin B as ovarian reserve markers of patients undergoing chemotherapy due to cancer or autoimmune diseases”.

Recent Publications

• Winkler, S. Ayuandari, V. Nederegger, S. Hofer, I. Zervomanolakis, D. Rosenfellner, L. Wildt, S.C. Ziehr. Physiological initiation of early follicular growth in fresh and frozen/thawed prepubertal murineovarian tissue after dynamic in vitro culture. ESHRE, Hum Reprod 2014, 40:166.

•  I. Zervomanolakis, M. Pitsos, G. Palmer, K. Winkler, L. Wildt. Follikelbildung nach Retransplantation vom Ovarialgewebe: Ein Fallbericht. OEGRM-Kongress,Innsbruck 2013.

• Winkler, S. Ayuandari,L. Wildt., I. Zervomanolakis, S.C. Ziehr. Dynamic perifusion culture initiates in vivo early follicular growth in prepubertal murine ovarian tissue. ESHRE, Hum Reprod 2013, 28:48.

• Ι. Zervomanolakis, Ι. Karagiorga, D. Mavrogianni, V. Dinopoulou, D. Loutradis. Einfluss der Einzelnukleotid-Polymorphismen (SNP) in Genen des Anti- Müller-Hormons und seines Typ-II-Rezeptors auf die Behandlung im Rahmen der assistierten Reproduktion. DGGG-Kongress, Munich 2012.

• Zervomanolakis, P. Giles, C. Sofoudis, N. Vlahos, V. Gregoriou, I. Galani. Estimating follicle survival through fluorescence microscopy of ovarian tissue after cryopreservation and thawing. ‘Fertility preservation: from endometriosis to ovarian tissue cryopreservation’, Brussels 2012.

• Ι. Zervomanolakis, L. Wildt, U. Siebert, W. Oberaigner. Effects of healthcare modernisation law on infertility treatment outcomes in Germany: a retrospective study. ESHRE, Hum Reprod 2011, 26: 223.

• Leydig-Cell-Tumor of the Ovary that Responded to GnRH-Analogue Administration – Case Report and Review of the Literature. RK Klotz, E Müller-Holzner, S Fessler, DU Reimer, I Zervomanolakis, B Seeber, V Mattle, L Wildt. Exp Clin Endocrinol Diabetes. 2010 May;118(5):291-7.

• K Winkler., S Hofer.,K.F. Murach, I Berger, M Drerup, L Wildt, I Zervomanolakis. Establishment of a perifusion system for stimulation of murine ovarian tissue in vitro. ESHRE, Hum Reprod 2009; 24:200.

• Zervomanolakis, H.W. Ott, J. Müller, B. E. Seeber, V. Mattle, I. Virgolini, D. Heute, L. Wildt. Uterine mechanisms of ipsilateral directed spermatozoa transport: Evidence for a contribution of the utero-ovarian countercurrent system. Eur J Obstet Gynecol Reprod Biol. 2009 May;144 Suppl 1:S45-9

• S. Foeger, M. Pichler, S. Reifer, E. Gunsilius, G. Gastl, L. Wildt, I. Zervomanolakis. Amenorrhoe nach zytotoxischer Therapie bei Frauen mit Hodgkin- und Nonhodgkin-Lymphomen. J. Reproduktionsmed. Endokrinol. 2008; 5 (5), 291.

• K. Winkler, S. Hofer, I. Berger, L. Wildt,I. Zervomanolakis: Entwicklung eines Perifusionssystems zur In-vitro Maturation und In-vitro Stimulation murinen Ovargewebes. OEGGG-Kongress, Mai 2008, Dornbirn.

• I. Zervomanolakis, S. Hofer, V. Mattle, K. Winkler, K. F. Murach, I. Berger, L. Wildt: Kinderwunsch nach Chemotherapie – wissenschaftliche Perspektiven und klinische Anwendung. J Gynäkol Endokrinol 2008; 18 (1): 7–13.

• Mattle V, A. Bilgyicildirim, D. Hadziomerovic, HW Ott, I. Zervomanolakis, G. Leyendecker, L. Wildt. Polycystic ovarian disease unmasked by pulsatile GnRH therapy in a subgroup of women with hypothalamic Amenorrhea. Fertil Steril. 2008 Feb;89(2):404-9.

•  „AMH und Inhibin B als Marker der ovariellen Funktionsreserve bei Patientinnen unter Chemotherapie auf Grund Krebs- und Autoimmunerkrankungen“. OEGRM-Κongress, September 2007, Innsbruck.

• I Zervomanolakis, V Mattle, KF Murach, S Hofer, L Wildt. Innsbrucker Konzept zum Fertilitätserhalt bei Patientinnen mit Krebs- und Autoimmunerkrankungen.   Geburtsh Frauenheilk 2007; 67.

• I Zervomanolakis, V Mattle, KF Murach, S Hofer, HW Ott, L Wildt. Cryopreservation of ovarian tissue: A new fertility preservation option for female patients with malignancies and autoimmune diseases. Exp Clin Endocrinol Diabetes 2007; 115

• I. Zervomanolakis, H.W. Ott, D. Hadziomerovic, V. Mattle, D. Heute und L. Wildt: Physiology of upward-transport in the human female genital tract. Annals of the New York Academy of Sciences. 2007 Apr; 1101:1-20